Abcam, ab95966, Anti-TUBA1A antibody - Loading Control

Size: 50µL
Rabbit Polyclonal TBA1A acetyl K40 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Drosophila melanogaster, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TUBA1A acetyl K40 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human, Drosophila melanogaster,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TUBA1A acetyl K40 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q71U36

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TUBA1A also known as alpha-tubulin 1A or Tubulin Alpha-1A Chain is a protein with a molecular mass of about 50 kDa. It is an important subunit of tubulin which polymerizes to form microtubules essential components of the cytoskeleton. TUBA1A is expressed in a wide range of tissues but shows higher levels in the central nervous system as tubulin forms the structural framework necessary for neuron function and cellular integrity.
Biological function summary
The TUBA1A protein functions in the assembly and disassembly of microtubules participating as part of the heterodimeric tubulin complex along with beta-tubulin. This structure allows microtubules to contribute to intracellular transport cell motility and chromosome segregation during cell division. The dynamic instability of microtubules facilitated by tubulin proteins like TUBA1A is important for the adaptive cellular functions.
Pathways
TUBA1A plays a role in the microtubule-associated processes being involved in the MAPK/ERK pathway and the mTOR signaling pathway. These pathways are important for cell growth differentiation and survival. TUBA1A's interaction with other microtubule-associated proteins regulates these signaling events and it also associates with proteins such as MAP2 or tau influencing the organization of microtubule networks.
Mutations in the TUBA1A gene relate to conditions like lissencephaly and microlissencephaly which affect brain development and lead to neurological deficits. In these disorders TUBA1A mutations disrupt normal microtubule function often influencing other proteins such as LIS1 which is critical for proper neuronal migration. Understanding TUBA1A's role can help in diagnosing and exploring therapeutics for such neurological conditions.