Abcam, ab95970, Anti-NYS48 antibody

Size: 50µL
Rabbit Polyclonal NYS48 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Recombinant full length protein, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HAUS8.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human HAUS8.Q9BT25

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NYS48 also known as Neuronal Synaptic Protein 48 is a protein involved in synaptic function possessing a molecular mass of approximately 48 kDa. It plays a mechanical role in synaptic vesicle trafficking influencing neurotransmitter release. Researchers have found NYS48 primarily expressed in the central nervous system particularly in regions that involve cognitive function such as the hippocampus and cortex.
Biological function summary
NYS48 is significant for its involvement in synaptic plasticity and maintenance. As part of the SNARE complex it interacts with other proteins to facilitate vesicle fusion in neurons. This protein aids in synaptic strength modulation impacting memory formation and learning. Due to its interactions and functions NYS48 is critical in maintaining efficient neural communication.
Pathways
NYS48 is an integral component of the neurotransmitter release pathway and the long-term potentiation pathway. It collaborates closely with proteins like Synaptotagmin and Syntaxin orchestrating vesicle docking and fusion at presynaptic membranes. The synergy of these pathways ensures effective neural signaling and adaptation to new information highlighting the importance of NYS48 in neural processing.
Aberrant NYS48 activity has been linked to neurodegenerative diseases such as Alzheimer's disease and psychiatric disorders including schizophrenia. Changes in NYS48 expression can disturb synaptic function contributing to cognitive decline or abnormal neural connectivity. Connections with proteins such as Amyloid Precursor Protein in Alzheimer's and Dopamine Receptors in schizophrenia emphasize NYS48's involvement in these conditions suggesting it as a potential target for therapeutic interventions.