Abcam, ab95993, Anti-Importin 13 antibody

Size: 50µL
Rabbit Polyclonal Importin 13 antibody. Suitable for WB, IP and reacts with Rat, Transfected cell lysate, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IPO13 aa 900 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IPO13 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O94829

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Importin 13 also known as IPO13 is a karyopherin with a molecular mass of approximately 100 kDa. This protein shuttles cargo between the cytoplasm and nucleus facilitating the nuclear import of various proteins and some RNAs. It expresses in many tissues with higher levels observed in brain testes and heart. Importin 13's transport function plays a significant role in regulating nuclear-cytoplasmic trafficking which is critical for cellular function and communication.
Biological function summary
The role of Importin 13 extends beyond simple transportation. It interacts with other proteins to regulate transcription and is sometimes part of a larger protein complex. Importin 13 helps in the import of transcription factors and other regulatory molecules into the nucleus influencing gene expression that affects cell differentiation and development. Its activity contributes to maintaining proper cellular states and transitions impacting processes such as neurogenesis and spermatogenesis.
Pathways
Importin 13 is intimately involved in the MAPK/ERK signaling pathway which determines cell growth and differentiation. It closely interacts with proteins like ERK2 facilitating their correct localization and function within the cell. These interactions ensure the precise regulation and execution of signaling events within the pathway enabling cells to respond correctly to extracellular signals. Additionally Importin 13 participates in the Wnt/β-catenin pathway further affecting cellular growth and development.
Importin 13's dysfunction connects to neurological disorders and cancer. Abnormal expression or mutations can contribute to developmental brain disorders due to its impact on neurogenesis. It has associations with cancer especially through pathways involving ERK2 and β-catenin where improper localization and activation might lead to uncontrolled cell growth. Studying Importin 13 offers insights into these conditions prompting potential therapeutic interventions.