Abcam, ab96083, Anti-ZHX2 antibody

Size: 50µL
Rabbit Polyclonal ZHX2 antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZHX2 aa 500-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZHX2 aa 500-800. The exact immunogen used to generate this antibody is proprietary information.Q9Y6X8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Zinc fingers and homeoboxes protein 2 (ZHX2) is a transcriptional repressor with an approximate molecular mass of 95 kDa. ZHX2 is expressed in various tissues including the liver kidney and spleen and it plays a role in regulating gene expression by binding to specific DNA sequences. Also known as zinc fingers and homeoboxes protein 2 ZHX2 contains two C2H2-type zinc finger domains and four homeobox domains which enable its DNA-binding ability and interaction with other proteins.
Biological function summary
ZHX2 impacts gene regulation by interacting with other transcription factors. It is known to associate with ZHX1 and NF-YA to form a protein complex that modulates the expression of various target genes. Through these interactions ZHX2 influences cell division differentiation and survival. It can act as a transcriptional repressor by binding to promoter regions of genes therefore modulating their expression levels in cellular contexts.
Pathways
ZHX2 influences several biological processes. It is involved in the Wnt signaling pathway where it can influence cellular proliferation and differentiation by regulating the expression of target genes. Additionally ZHX2 interacts with the pathways governed by the transforming growth factor-beta (TGF-β) family which are important for cellular proliferation differentiation and apoptosis. ZHX2 can modulate these pathways by interacting with proteins such as SMAD2/3 and β-catenin impacting their downstream effects.
ZHX2 has been linked to cancer progression and autoimmune diseases. In certain cancers ZHX2 expression levels correlate with tumor progression suggesting it may serve as a potential marker or therapeutic target. ZHX2 influences the expression of oncogenes and tumor suppressor genes in this context. In autoimmune conditions it has been implicated in abnormal immune responses potentially by regulating genes involved in immune cell function. Through these diseases ZHX2 is associated with proteins like p53 in cancer and NF-κB in autoimmune disorders affecting their signaling and regulatory roles.