Abcam, ab96236, Anti-MAGEA11 antibody

Size: 50µL
Rabbit Polyclonal MAGEA11 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MAGEA11 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MAGEA11 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.P43364,
Specificity:It is likely that the antibody will cross-react with other proteins of the MAGE family. This information is based on BLAST homology and has not been verified experimentally. Please contact our Scientific Support for further information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAGEA11 also known as Melanoma Antigen Family A11 is involved in the regulation of androgen receptor activity. This protein has a mass of approximately 38 kDa. It is mainly expressed in various cancerous tissues and certain normal tissues such as the testis. MAGEA11 functions by interacting with androgen receptors and modulating their transcriptional activity which plays a significant role in cellular growth and differentiation especially in hormone-sensitive cells.
Biological function summary
MAGEA11 modulates androgen receptor signaling pathways. It does not form part of a complex but actively participates in the enhancement of the receptor's transcriptional activity. This activity affects cell proliferation and can influence cancer progression. MAGEA11 expression in normal tissues remains limited implying its role is mostly in disease states or specific developmental stages.
Pathways
MAGEA11 has a significant role in the androgen receptor signaling pathway and cellular response pathways to hormonal stimuli. It enhances the interaction between androgen receptors and other co-regulators such as AR-associated proteins. By modulating this pathway MAGEA11 interacts with proteins like p300 which is involved in the transcription regulation by histone acetylation thereby influencing gene expression linked to growth and development.
MAGEA11 has a connection with prostate cancer and certain melanoma forms. In prostate cancer MAGEA11's overexpression leads to heightened androgen receptor activity promoting disease progression. The protein interacts with p300 in these conditions affecting gene transcription associated with cancer cell proliferation. Understanding these interactions aids in decoding the molecular mechanisms of hormone-related cancers offering potential therapeutic targets.