Abcam, ab96431, Anti-HSV2 ICP4 antibody

Size: 50µg
Rabbit Polyclonal Varicella Zoster Virus IE62 antibody. Suitable for ELISA, WB and reacts with Recombinant fragment - Human herpesvirus 2 samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purity is >90%, Storage buffer-pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HSV2 ICP4 also known as Infected Cell Polypeptide 4 is a significant transcriptional regulator in Herpes Simplex Virus type 2. It works as a major transcription factor necessary for virus replication. ICP4 weighs approximately 160 kDa. It expresses abundantly in cells infected by HSV2 leading to changes in cell function necessary for viral replication. ICP4 binds to DNA in a sequence-specific manner and activates transcription of most viral genes.
Biological function summary
ICP4 is essential to switch on the expression of viral genes during the lytic phase. It is not part of a complex but acts by binding directly to the viral DNA. The protein's function influences the viral lifecycle driving progression into the productive phase. By regulating gene expression ICP4 ensures viral proteins are synthesized in a timely manner during infection.
Pathways
ICP4 plays an instrumental role in the transcriptional activation of HSV2’s gene expression cascade. This pathway includes the viral immediate early (IE) early (E) and late (L) genes ensuring cycle progression. Besides ICP4 regulates interactions with other viral proteins like ICP0 and ICP27 which help maintain efficient replication and transcription processes in infected cells.
ICP4 is closely associated with conditions caused by HSV2 such as genital herpes and its complications. Its constant activity in viral gene regulation makes it a potential target for therapeutic interventions aimed at controlling infection. ICP4’s interplay with ICP0 is critical in viral reactivation contributing to the pathology of recurrent infections.