Abcam, ab96803, Anti-ATP6V0A2 antibody

Size: 100µL
Rabbit Polyclonal ATP6V0A2 antibody. Suitable for WB and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ATP6V0A2 aa 150-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ATP6V0A2 aa 150-450. The exact immunogen used to generate this antibody is proprietary information.Q9Y487

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP6V0A2 also known as V-ATPase V0 subunit a2 is a component of the vacuolar-type H+-ATPase (V-ATPase) complex. This protein plays a mechanical role in proton translocation across intracellular and plasma membranes. The molecular mass of ATP6V0A2 is approximately 100 kDa. It is widely expressed in many tissues with significant levels in the brain kidney and liver. This expression pattern suggests its functionality is essential across various cellular types and organs.
Biological function summary
ATP6V0A2 contributes to acidification of intracellular compartments such as endosomes lysosomes and the Golgi apparatus. It is part of the larger V-ATPase complex which is critical for processes like protein sorting zymogen activation and receptor-mediated endocytosis. By maintaining the acidic environment within cellular organelles ATP6V0A2 supports the optimal activity of enzymes and influences membrane trafficking impacting cellular homeostasis.
Pathways
ATP6V0A2 influences processes integral to the endocytic and autophagic pathways. These pathways are essential for the degradation and recycling of cellular components. The protein interacts with components of these pathways such as those involved in lysosomal function hinting at its broader involvement in maintaining cellular health. ATP6V0A2 plays a functional role alongside other subunits of the V-ATPase complex in pathways that regulate intracellular pH balance and cellular metabolism.
Defects in ATP6V0A2 are linked to autosomal recessive cutis laxa type II a disorder characterized by loose skin and systemic involvement including developmental delays. Alterations in this protein can also influence the pathology of neurodegenerative diseases. The disorder's connection involves interactions with other proteins such as collagens which are affected by changes in the pH of the secretory pathway highlighting the importance of ATP6V0A2 in maintaining proper cellular microenvironments.