Abcam, ab97644, Anti-C9orf78 antibody

Size: 50µL
Rabbit Polyclonal C9orf78 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human C9orf78 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human C9orf78 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9NZ63

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C9orf78 also known as chromosome 9 open reading frame 78 is a protein with a molecular mass of approximately 24 kDa. It is expressed in various tissues but shows higher levels in the lung and reproductive organs. On a mechanical level C9orf78 is involved in intracellular processes where it interacts with other cellular components indicating its role in cellular signaling and regulation.
Biological function summary
C9orf78 plays a role in cellular homeostasis and regulation of metabolic processes. It acts as part of a complex that modulates cellular responses to stress and can influence gene expression. The protein's involvement in these cellular processes suggests that it serves as a mediator between cellular signaling pathways and the physical expression of cellular responses.
Pathways
C9orf78 contributes significantly to the AMPK signaling pathway and interacts with various proteins including LKB1. This association positions it as an important factor in energy metabolism helping the cell respond to energy depletion. Its role in the cellular energy balance connects it closely to upstream and downstream signals that control cellular growth and metabolism making it important for maintaining cellular function.
C9orf78 is associated with complex conditions like metabolic syndrome and cancer. It links to disease progression possibly through its relationship with AMPK as dysregulation in this pathway can lead to metabolic imbalance and growth irregularities. Additionally its interaction with proteins like LKB1 known for its tumor suppressive functions further emphasizes the importance of C9orf78 in maintaining normal cellular operations and its potential impact when malfunctioning.