Abcam, ab97648, Anti-DDX56/DDX21 antibody

Size: 50µL
Rabbit Polyclonal DDX56/DDX21 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DDX56 aa 250-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DDX56 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.Q9NY93

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DDX56 also known as DDX21 is a protein that is part of the DExD/H-box family of RNA helicases. This protein has an approximate mass of 87 kDa and functions in the unwinding of RNA carrying out ATP-dependent helicase activity. DDX56 is widely expressed in human cells with a particular abundance in the nucleolus where it plays an important role in the formation and processing of ribosomal RNA.
Biological function summary
DDX56 acts in the regulation of ribosome assembly and ribosomal RNA processing. This protein is involved in the transcription and maturation of pre-rRNA an important step in ribosome biogenesis. DDX56 forms part of the small subunit (SSU) processome complex which contains various proteins necessary for early stages of ribosome assembly. The SSU processome is essential for the processing of primary rRNA transcripts into 18S rRNA.
Pathways
DDX56 is important in ribosome biogenesis and RNA transcription. It interacts with components of the RNA polymerase I pathway which is responsible for the transcription of rRNA genes. DDX56 also associates with the snoRNP complexes involved in the modification and processing of rRNA. Its activity affects proteins like fibrillarin and U3 snoRNA which are required for rRNA processing and ribosome assembly.
Researchers have linked DDX56 to certain cancers such as breast cancer and prostate cancer. In these conditions DDX56 often shows altered expression which impacts ribosome biogenesis and cellular proliferation. The protein interacts with nucleolin another nucleolar protein which modulates rRNA synthesis. This relationship plays a role in the progression of cancer making DDX56 a potential target for therapeutic intervention in these diseases.