Abcam, ab97682, Anti-SGLT1 antibody

Size: 100µg
Rabbit Polyclonal SGLT1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC5A1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC5A1. The exact immunogen used to generate this antibody is proprietary information.P13866

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 3711 SGLT-1 Antibody. 3711-100 is the same size as the 100 µg size of ab97682.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SGLT1 also known as sodium/glucose cotransporter 1 or SLC5A1 is a membrane protein actively responsible for glucose and galactose uptake in the small intestine and renal tubules. It has a molecular mass of approximately 73 kDa. Expressed mainly in the brush border of the enterocytes in the small intestinal lining and to a lesser degree in the kidney SGLT1 functions by coupling the transport of glucose to sodium ions' electrochemical gradient enabling effective nutrient absorption.
Biological function summary
SGLT1's main role is in facilitating nutrient absorption in the gastrointestinal tract. It operates as part of the larger SGLT protein family but does not form a complex with other proteins. The protein is essential for the transport of monosaccharides from the gut into circulation. By ensuring glucose and galactose absorption during digestive processes SGLT1 provides necessary carbohydrates for cellular metabolism and systemic energy homeostasis.
Pathways
The transport protein SGLT1 is integral to the glucose uptake pathway. This pathway intersects with the insulin signaling pathway because the glucose absorbed by SGLT1 later enters systemic circulation. SGLT1 also complements the GLUT family of transporters especially GLUT2 which function downstream by facilitating glucose transport across the intestinal basolateral membrane into the bloodstream. The interplay between these transport mechanisms maintains glucose levels post-ingestion.
SGLT1 dysfunction is linked to glucose-galactose malabsorption a genetic disorder causing severe dehydration and diarrhea due to glucose and galactose accumulation in the lumen. Additionally research investigates SGLT1's contribution to diabetes management given its role in glucose absorption. The protein's activity along with related proteins like GLUT2 and GLUT4 could influence insulin resistance and glucose homeostasis in metabolic syndromes. Understanding SGLT1 in these contexts enables potential therapeutic interventions for conditions involving disordered glucose metabolism.