Abcam, ab9774, Anti-Endothelial Cell antibody [RECA-1]

Size: 100µg
Anti-Endothelial Cell antibody [RECA-1] (ab9774) is a mouse monoclonal antibody detecting Endothelial Cell in IHC-P . Suitable for Rat . - Over 100 publications - Trusted since 2002
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:RECA-1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What is this antibody validated in?
Anti-Endothelial Cell antibody [RECA-1] (ab9774) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Rat samples.
Trusted by the scientific community
Anti-Endothelial Cell [RECA-1] (ab9774) was first used in a scientific publication in 2002 and has been cited over 100 times in peer-reviewed journals.
Reviewed by scientists
Anti-Endothelial Cell [RECA-1] (ab9774) has over 15 independent reviews from customers.
Other related products
We have a range of other formats of antibody clone [RECA-1] also available for your convenience: ab9774, Alexa Fluor® 488 -
ab197727
, Carrier free -
ab264524
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Endothelial cells sometimes referred to as endothelium form the thin layer of approximately 1-2 µm thickness that lines the interior surface of blood vessels and lymphatic vessels. They possess a considerable array of roles mainly being a barrier between the vessel lumen and surrounding tissue and they regulate the passage of materials and the transit of white blood cells into and out of the bloodstream. Endothelial cells are widespread found in veins arteries capillaries and the heart. These cells express a variety of markers used to identify them and antibodies targeting endothelial markers are valuable tools in research and diagnostics.
Biological function summary
Endothelial cells maintain vascular tone and blood fluidity and they mediate angiogenesis which is the development of new blood vessels from pre-existing ones. They achieve these functions through the expression of adhesion molecules and growth factors. Endothelial cells contribute to the formation of a selective permeability barrier and respond to mechanical and chemical signals. They do not function alone; they are part of a larger vascular complex that includes smooth muscle cells and pericytes.
Pathways
Endothelial cells play key roles in the nitric oxide (NO) signaling and angiogenesis pathways. They produce nitric oxide a critical molecule for vasodilation and blood pressure regulation through the action of enzymes like endothelial nitric oxide synthase (eNOS). In the angiogenesis pathway endothelial cells interact with proteins like vascular endothelial growth factor (VEGF) which signals the proliferation and migration processes necessary for new blood vessel formation.
Endothelial dysfunction links to cardiovascular conditions like atherosclerosis and hypertension. Damage or alteration in endothelial cell function can lead to abnormal vascular behavior. Oxidative stress and inflammation often disrupt endothelial activity involving proteins such as E-selectin and intercellular adhesion molecule-1 (ICAM-1) contributing to disease progression. Understanding these associations highlights the importance of endothelial cell studies in addressing cardiovascular disorders.