Abcam, ab97867, Anti-SUCLG1 antibody

Size: 50µL
Rabbit Polyclonal SUCLG1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SUCLG1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SUCLG1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P53597

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SUCLG1 also known as succinate-CoA ligase (GDP-forming) subunit alpha participates in cellular energy metabolism. It catalyzes the conversion of succinyl-CoA to succinate in the mitochondria linking the citric acid cycle and oxidative phosphorylation. SUCLG1 has a molecular mass of approximately 32 kDa. This protein expresses highly in metabolically active tissues such as the liver kidney and brain where energy demand is significant.
Biological function summary
Succinate-CoA ligase facilitates the synthesis of nucleoside triphosphates within the mitochondria by participating in the GDP-specific form of the enzyme complex. SUCLG1 forms a heterodimer with SUCLG2 (the beta subunit) creating succinate-CoA ligase's functional enzyme complex. Through its action SUCLG1 directly impacts the generation of GTP which plays a critical role in modulating metabolic reactions within cells.
Pathways
Succinate-CoA ligase integrates into the citric acid cycle and plays a significant role in cellular respiration. By converting succinyl-CoA to succinate it helps sustain the cycle's continued operation. The protein also links with nucleoside diphosphate kinase which governs the maintenance of cellular nucleotide balance. These interactions highlight the essential nature of SUCLG1 in maintaining energy flow within cells.
Mutations in SUCLG1 associate with mitochondrial DNA depletion syndromes which severely affect muscle and brain tissue. Dysfunction within succinate-CoA ligase disrupts the energy production process leading to cellular energy deficits. Additionally this protein’s interaction with SUCLG2 implies potential implications in similar disorders related to mitochondrial function showing the importance of their combined activity in maintaining cellular health.