Abcam, ab97910, Anti-MCPIP1 antibody

Size: 100µL
Rabbit Polyclonal MCPIP1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZC3H12A aa 250-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZC3H12A aa 250-500. The exact immunogen used to generate this antibody is proprietary information.Q5D1E8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MCPIP1 (Monocyte Chemotactic Protein-Induced Protein 1) also known by the name Regnase-1 is a protein involved in RNA degradation and inflammation regulation. It acts as an RNase specifically targeting mRNAs for degradation impacting gene expression post-transcriptionally. The protein weighs around 66 kDa and shows expression in various tissues including heart spleen and macrophages. MCPIP1 also demonstrates notable expression in response to external stimuli like lipopolysaccharides.
Biological function summary
MCPIP1 modulates the immune response and inflammation by degrading mRNA of cytokines. Its action helps in controlling inflammation and immune response duration. MCPIP1 interacts with cellular complexes that manage mRNA stability including those involved in decay processes. This activity positions MCPIP1 as a regulator in the production of pro-inflammatory cytokines contributing to the cellular response to external pathogens.
Pathways
MCPIP1 functions within the inflammatory and immune signaling pathways. It is involved in the MAPK pathway which regulates gene expression in response to stress and cytokines. MCPIP1 also interacts with proteins such as TNF-alpha and IL-6 linking it to the inflammatory signaling cascade. These interactions highlight MCPIP1's role in mediating immune and inflammatory pathways contributing to maintaining cellular homeostasis.
MCPIP1 connections relate to inflammatory diseases and autoimmune disorders. Aberrant expression or malfunction of MCPIP1 associates with pathological conditions including rheumatoid arthritis and systemic lupus erythematosus. The regulation of cytokines by MCPIP1 positions it centrally in these conditions as inappropriate levels of proteins like IL-6 and TNF-alpha contribute to disease progression. Consequently MCPIP1 serves as a potential therapeutic target in managing inflammation-driven diseases.