Abcam, ab99273, Anti-Importin 7 antibody

Size: 100µL
Rabbit Polyclonal Importin 7 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Cited in 17 publications. Immunogen corresponding to Synthetic Peptide within Human IPO7 aa 200-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IPO7 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.O95373

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab99273 was affinity purified using an epitope specific to Importin 7 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Importin 7 also known as IPO7 is a nuclear transport receptor with a mass of approximately 120 kDa. It facilitates the import of proteins into the nucleus recognizing nuclear localization signals and interacting with the nuclear pore complex. Importin 7 is expressed in various tissues with higher expression levels observed in proliferating cells. It acts independently or in conjunction with importin-beta to mediate transport processes essential for maintaining cellular function.
Biological function summary
Importin 7 participates in the active transport of macromolecules between the cytoplasm and the nucleus. It functions as an important component of the importin superfamily which plays a role in nuclear-cytoplasmic trafficking. Importin 7 can form a complex with importin-beta to transport large cargo requiring importin-alpha therefore indicating its versatility in transport mechanisms. The ability to bind different cargo allows it to regulate transcription factors and other nuclear proteins impacting gene expression and cellular responses.
Pathways
Importin 7 is involved in the nuclear import pathway and participates in the regulation of gene expression. It is integral to the translocation of SMAD proteins which are part of the TGF-beta signaling pathway. The interaction of importin 7 with importin-beta underlines its function in these pathways meticulously controlling the movement of signaling molecules into the nucleus to impact cellular growth processes and differentiation events.
Importin 7 links to cancer and viral infections. Altered expression or mutations may affect nuclear transport contributing to tumorigenesis by disrupting nuclear signaling pathways. In cancer importin 7's relationship with proteins such as p53 can influence the progression of the disease by modifying transcriptional regulatory activities. In viral infections it interacts with viral proteins that hijack the nuclear import machinery allowing viruses to replicate and evade the host immune response.