Abcam, ab99351, Anti-KANK2 antibody

Size: 100µg
Rabbit Polyclonal KANK2 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KANK2 aa 550-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human KANK2 aa 550-600. The exact immunogen used to generate this antibody is proprietary information.Q63ZY3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, PBS, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The KANK2 protein or KN motif and ankyrin repeat domains 2 plays a role in modulating the cytoskeleton by interacting with the actin network. It weighs around 86 kDa. KANK2 is expressed in various tissues with notable levels in the kidneys and testes. Its location in the cell membrane allows it to contribute to maintaining cellular structure and enabling intracellular communication.
Biological function summary
KANK2 interacts with multiple proteins and is a part of a protein complex involved in cytoskeletal organization. It functions by modulating microtubule dynamics and stabilizing cell-cell junctions impacting cellular adhesion and migration processes. The ankyrin repeat domains in KANK2 facilitate these interactions which are essential for the integrity and function of cellular structures.
Pathways
KANK2 participates in signaling pathways related to cytoskeleton rearrangement and cell adhesion. It interacts with proteins such as Rho GTPases that regulate these pathways. Through these interactions KANK2 plays a role in controlling cell shape and motility which are significant in processes like wound healing and embryonic development.
Alterations in KANK2 expression or function have associations with diseases like nephrotic syndrome and some cancers. In nephrotic syndrome KANK2 mutations can disrupt the kidney filtration barrier leading to the condition. Its interaction with proteins such as nephrin highlights its role in maintaining podocyte function which is important in kidney health.