Abcam, ab99353, Anti-ZHX3 antibody

Size: 100µL
Rabbit Polyclonal ZHX3 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ZHX3 aa 900 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZHX3 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H4I2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZHX3 also known as Zinc Fingers and Homeoboxes 3 is a transcription factor with a molecular weight of approximately 100 kDa. It is composed of two C2H2-type zinc fingers and a homeobox domain which contribute to its DNA-binding abilities. ZHX3 expresses predominantly in the liver kidney and pancreas where it plays roles in regulating the expression of various genes. The protein's presence in these organs emphasizes its importance in controlling gene activity related to specific physiological functions.
Biological function summary
ZHX3 acts as a transcriptional repressor that works within multi-protein complexes to modulate gene expression. It interacts with other members of the ZHX family and operates in concert with a protein called NF-YA to affect the transcriptional landscape of a cell. Through these interactions ZHX3 impacts cellular processes such as differentiation growth and apoptosis. This protein's activity is essential for maintaining proper cellular functions and ensuring that cells respond correctly to internal and external cues.
Pathways
ZHX3 participates in vital transcriptional regulatory networks. These networks influence cell cycle control and apoptosis both important to normal cellular proliferation and overall homeostasis. In these pathways ZHX3 often interacts with proteins like ZHX2 and NF-YA forming complexes that facilitate its role as a transcriptional regulator. The function of ZHX3 is critical in these pathways to maintain the balance between cell survival and death.
Disruptions in ZHX3 function have implications in certain types of cancer notably hepatocellular carcinoma and renal cell carcinoma. Altered expression or mutation of ZHX3 can lead to dysregulated cell cycles and evasion of apoptosis contributing to tumorigenesis. In cancer ZHX3 interactions with proteins such as p53 and NF-YA become significant as they can influence tumor progression. Understanding ZHX3's role in these diseases can provide insights into potential therapeutic targets for drug development.