Agilent, PL1180-5302, AdvanceBio SEC 1000 Å, 2.7 µm, 7.8 x 300 mm

AdvanceBio SEC 1000 Å, 2.7 µm, 7.8 x 300 mm. Size exclusion column for aggregate analysis of large biological molecules, such as VLPs and large oligonucleotides.

Specifications:
Brand: AdvanceBio SEC
Guard Column: No
Hardware: SS
Inner Diameter (ID): 7.8 mm
Length: 300 mm
Maximum Temperature: 80 °C
Molecular Weight Lower Limit: 15000 Da
Molecular Weight Upper Limit: 10 MDa
Particle Size: 2.7 µm
Particle Type: Fully Porous
Phase: SEC
Pore Size: 1000 Å
Pressure Rating: 400 bar
Separation Mode: Size Exclusion (SEC)
Shipping Solvent: Phosphate Buffer/0.02% Sodium azide
Storage Temp Conditions: Store at room temperature
pH Range: 2-8.5

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The AdvanceBio SEC 1000 Å, 2.7 µm, 7.8 x 300 mm column is designed for high-resolution size exclusion chromatography applications in biopharmaceutical research and development. Featuring a 1000 angstrom pore size and 2.7 micron particle technology, this column facilitates accurate molecular size separation and aggregate analysis of proteins, monoclonal antibodies, and other biomolecules. Its optimized dimensions support superior performance, high efficiency, and excellent reproducibility for both routine quality control and detailed characterization studies.

Primarily used for molecular weight determination and aggregation analysis, this column is ideal for characterizing protein purity, identifying oligomeric states, and performing stability assessments. It is compatible with a broad range of aqueous buffers and is well suited for use with high-performance liquid chromatography systems, including Agilent’s InfinityLab LC Series and 1260 Infinity Bio-inert systems. The robust design ensures durability under demanding laboratory conditions and enables reliable performance with various sample types.

Related products, such as the AdvanceBio SEC 300 Å and SEC 1200 Å columns, offer alternative pore sizes to optimize separations based on molecular size requirements. This column is an essential component for laboratories working on protein therapeutics, biosimilar development, and detailed characterization of biologics.