Agilent, PL1512-3801, Agilent PLRP-S 300Å, 4.6 x 150 mm, 8 µm

Agilent PLRP-S 300Å, 4.6 x 150 mm, 8 µm. Reversed-phase HPLC column with fully porous PS/DVB particle support stable at elevated temperatures and a wide pH range(1-14). Available in range of particle and pore sizes for targeted applications

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This reversed-phase HPLC column features a 300 angstrom pore size, 4.6 mm internal diameter, 150 mm length, and 8 micron particle size, making it ideal for the analysis and purification of large biomolecules such as proteins, peptides, and oligonucleotides. Its rigid polymeric particle chemistry delivers excellent stability and reproducibility across a wide pH range, enabling robust separations and reliable results even under demanding conditions. The column supports efficient mass transfer, minimizing band broadening and maximizing resolution in analytical and semi-preparative workflows.

Common applications include protein variant characterization, peptide mapping, and biomolecule purity assessments in biotechnology, pharmaceutical, and academic laboratories. It is especially suited for reversed-phase chromatography of fragile molecules due to its high mechanical strength and low non-specific adsorption. The column is compatible with a broad range of mobile phases, allowing users to optimize separations for various targets and matrices.

Engineered for seamless integration, it performs reliably with Agilent HPLC and UHPLC systems and most third-party liquid chromatography instruments. It aligns well with Agilent's lineup of polymer-based reversed-phase columns, facilitating method development and scalability. Its robust construction ensures prolonged column life and consistent performance, supporting high-throughput and high-sensitivity biomolecular analyses.