Biolegend, 110402, Purified anti-mouse CD202b (Tie-2, CD202) Antibody, 100μg

CD202b, also known as Tie-2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in the quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 also binds to Ang-4.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested IHC-F - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. For immunohistochemistry on frozen tissue sections, a concentration range of 5 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2922458 (BioLegend Cat. No. 110402)
Structure: The receptor tyrosine kinase (RTK) family
Distribution: Endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes
Cell Type: Endothelial cells, Epithelial cells, T cells
Biology Area: Angiogenesis, Cell Biology, Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Fathers KE, et al. 2005. Am. J. Pathol. 167:1753-62. Yano M, et al. 1997. Blood 89:4317-26. Kolatsi-Joannou M, et al. 2001. Dev. Dyn. 222:120-6.
Gene ID: 21687
UniProt: View information about CD202b on UniProt.org
Clone: W19424P
Regulatory Status: RUO
Other Names: Tie-2, TEK
Isotype: Rat IgG2b, κ