Biolegend, 115406, PE/Cyanine7 anti-mouse Integrin αVβ8 Antibody, 100μg

Integrins are heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix adhesion. Integrin αVβ8 is also involved in TGF-β activation, which contributes to regulatory T cell (Treg) activities.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse αVβ8 integrin-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes: Clone S20011E does not affect the binding of clone S20011B on target cells. Clone S20011E does not react with mouse integrin αVβ6.
RRID: AB_3662178 (BioLegend Cat. No. 115405) AB_3662178 (BioLegend Cat. No. 115406)
Structure: Integrins
Distribution: Epithelial cells
Function: Cell adhesion, TGF-β activation
Cell Type: Epithelial cells, Tregs
Biology Area: Cell Adhesion, Cell Biology, Immuno-Oncology, Immunology
Molecular Family: Adhesion Molecules
Antigen References: Moyle M, et al. 1991. J Biol Chem. 266:19650-8
Gene ID: 16410320910
UniProt: View information about Integrin alphaVbeta8 on UniProt.org
Clone: S20011E
Regulatory Status: RUO
Other Names: Integrin alpha V beta 8
Isotype: Rat IgG2b, λ