Biolegend, 117507, PE/Cyanine7 anti-mouse Integrin αVβ6 Antibody, 25μg

Integrins are heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix adhesion. Integrin β6 associates exclusively with the αV subunit forming an αVβ6 complex that is expressed specifically on epithelial cells. Integrin αVβ6 is a receptor for multiple extracellular matrix (ECM) proteins, including tenascin, fibronectin, and vitronectin. It is also a receptor for the latency-associated peptide (LAP) of TGF-β and is involved in TGF-β activation. Its expression is upregulated during wound healing and in some cancers.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse αvβ6 integrin-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes: Clone S20012B does not affect the binding of clone S20012E on target cells. Clone S20012B does not react with mouse integrin αVβ8.
RRID: AB_3698903 (BioLegend Cat. No. 117507) AB_3698903 (BioLegend Cat. No. 117508)
Structure: Integrins
Distribution: Epithelial cells
Function: Cell adhesion, TGF-β activation
Cell Type: Epithelial cells
Biology Area: Cell Adhesion, Cell Biology, Immunology
Molecular Family: Adhesion Molecules
Antigen References: Sheppard D, et al. 1990. J Biol Chem. 265:11502-7. Koivisto L, et al. 2018. Int J Biochem Cell Biol. 99:186-196.
Gene ID: 1641016420
UniProt: View information about Integrin alphaVbeta6 on UniProt.org
Clone: S20012B
Regulatory Status: RUO
Other Names: Integrin alpha V beta 6
Isotype: Rat IgG1, κ