Biolegend, 118702, Purified anti-mouse CD262 (DR5, TRAIL-R2) Antibody, 100μg

CD262, also known as DR5, TRAIL-R2, Apo-2, TRICK2, and KILLER, is a 55 kD protein. DR5 is member 10B of the TNF receptor superfamily (TNFRSF10B), widely expressed in normal tissues and some tumor cell lines. The DR5 receptor binds to TRAIL and interacts with the cytoplasmic proteins TRADD and RIP. TRAIL binding to DR5 activates NF- κB and induces apoptosis. DR5 is induced by wild-type p53.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse DR5-Ig fusion protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_3097171 (BioLegend Cat. No. 118702)
Structure: Type I transmembrane protein, TNF receptor superfamily member, homotrimer, predicted molecular weight 55 kD
Distribution: Widely expressed in normal tissues and some tumor cell lines. Expression regulated by the tumor suppressor p53.
Function: Binds to TRAIL, activates NF-κB, induces apoptosis. May be involved in the regulation of tumor metastases.
Interaction: The DR5 receptor binds to TRAIL and interacts with the cytoplasmic proteins TRADD and RIP.
Ligand/Receptor: TRAIL (CD253); cytoplasmic domain interacts with TRADD and RIP
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: Wu GS, et al. 1999. Cancer Res. 59:2770-5. Walczak H, et al. 1997. EMBO J. 16:5386-97. Shigeno M, et al. 2003. Oncogene. 22:1653-62. LaVallee T, et al. 2003. Cancer Res. 63:468-75. Nimmanapalli R, et al. 2001. Cancer Res. 61:759-63.
Gene ID: 21933
UniProt: View information about CD262 on UniProt.org
Clone: W18111A
Regulatory Status: RUO
Other Names: DR5, TRAIL-R2, TNFRS10B, TRICK2, KILLER
Isotype: Rat IgG2a, λ