Biolegend, 139904, PE anti-mouse TCR Vα11.1, 11.2 Antibody, 100μg

Vα11 T cell receptor (TCR Vα11) is a variant of TCR α chain and, along with TCR β chain, forms the TCR heterodimer. In association with the CD3 complex, TCR α/β is responsible for antigen recognition through the interaction with MHC-peptide complex to initiate the T cell-mediated immune responses. The RR8-1 antibody is specific for b and d haplotypes of TCR Vα11.1 and Vα11.2, but not for Vα11.3. It does not react with a and c haplotypes of TCR Vα11.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse T-cell clone B10
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References(PubMed link indicates BioLegend citation): Jameson SC, et al. 1991. J. Immunol. 147:3185. (FC)
RRID: AB_10640825 (BioLegend Cat. No. 139903) AB_10644000 (BioLegend Cat. No. 139904)
Structure: Member of the immunoglobulin superfamily, Vα11 is a variant of the TCR α chain which associates with the TCR β chain to form the TCR heterodimer.
Distribution: Subset of TCR αβ+ T cells.
Function: Recognition of peptides presented by MHC molecules, responsible for T cell mediated immune responses.
Ligand/Receptor: MHC-peptide complex
Cell Type: T cells
Biology Area: Adaptive Immunity, Immunology
Molecular Family: TCRs
Gene ID: 21473
UniProt: View information about TCR Valpha11.1 11.2 on UniProt.org
Clone: RR8-1
Regulatory Status: RUO
Other Names: Vα11 T-cell receptor,T cell receptor alpha 11
Isotype: Rat IgG2b, κ
Q: What type of PE do you use in your conjugates?
A: We use R-PE in our conjugates.