Biolegend, 150328, KIRAVIA Blue 520™ anti-mouse CD198 (CCR8) Antibody, 100μg

C-C chemokine receptor type 8 (CCR8) CD198, is a 41 kD G-protein coupled receptor with 7 transmembrane regions. CCR8 is expressed by a subset of thymocytes, Tregs, NKT and Th2-polarized cells, a subset of macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 mediates chemotaxis toward its ligand CCL1, and is involved in apoptosis of thymocytes.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse CD198 (CCR8)-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with KIRAVIA Blue 520™ under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * KIRAVIA Blue 520™ has an excitation maximum of 495 nm, and a maximum emission of 520 nm. KIRAVIA Blue™ 520 is a trademark of Sony. This product is subject to proprietary rights of Sony and is made and sold under license from Sony Corporation. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.Sony and the Sony logo are registered trademarks of Sony Corporation.
Excitation Laser: Blue Laser (488 nm)
RRID: AB_2890698 (BioLegend Cat. No. 150327) AB_2890698 (BioLegend Cat. No. 150328)
Structure: G-protein coupled receptor, 7 transmembrane regions, 41 kD.
Distribution: Thymocytes, Tregs, NKT and Th2-polarized cells, subset of macrophages, monocytes and monocyte-derived dendritic cells.
Function: Chemotaxis, involved in thymocyte apoptosis
Ligand/Receptor: CCL1 (SCY1,TCA-3)
Cell Type: Dendritic cells, Macrophages, Monocytes, NKT cells, Th2, Thymocytes, Tregs
Biology Area: Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References: 1. Coghill JM, et al. 2013. Blood. 122:825. 2. Islam SA, et al. 2011. Nat. Immunol. 12:167. 3. Hoshino A, et al. 2007. J. Immunol. 178:5296. 3. Qu C, et al. 2004. J. Exp. Med. 200:1231.
Gene ID: 12776
UniProt: View information about CD198 on UniProt.org
Clone: SA214G2
Regulatory Status: RUO
Other Names: CDw198, C-C chemokine receptor type 8, CKR-8, CC-CKR-8, Ter1
Isotype: Rat IgG2b, κ