Biolegend, 162802, Purified anti-mouse UNC93B1 Antibody, 100μg

Unc93b1 is a 12 pass transmembrane protein highly conserved in the endoplasmic reticulum (ER). Unc93b1 plays a role in the transport of TLRs from the ER to the cell surface or endosomes where they can engage pathogens nucleotides and trigger signaling cascades. Mutations in the Unc93b1 gene have shown to cause susceptibility to some common infections (HSV hypersensitivity in humans, and mouse cytomegalovirus).
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse UNC93B1-transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
RRID: AB_2888873 (BioLegend Cat. No. 162802)
Structure: 12 pass transmembrane protein
Antigen References: 1. Majer. et al. 2019. Nature. 575, 371–374 2. Pelka et al. 2018. Immunity. 48, 911–922 3. Huh et al. 2014. PNAS. 111, 7072–7077
Gene ID: 81622
UniProt: View information about UNC93B1 on UniProt.org
Clone: S19013C
Regulatory Status: RUO
Other Names: Unc-93 homolog B1, TLR signaling regulator
Isotype: Rat IgG2a, κ