Biolegend, 164302, Purified anti-mouse CD338 (ABCG2) Antibody, 100μg

CD338, also known as ABCG2 or BCRP1, is a 72 kD multi-drug resistance (MDR) protein member of ATP binding cassette (ABC) transporters. CD338 is expressed on stem cells from a variety of tissues and in many cancer types where it contributes to their resistance to chemotherapeutic drugs. ABCG2 is also up-regulated during erythroid differentiation. The expression of ABCG2 appears to be highly conserved as it has been identified in various species.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: mAbcg2-transfectants/ epitope is listed as extracellular domain
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality Tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2924495 (BioLegend Cat. No. 164302)
Structure: Member of the G subfamily of human ATP-binding cassette (ABC) transporter superfamily
Distribution: Stem cells from multiple lineages, erythroid cells, cancerous cells
Function: Acts as a xenobiotic efflux transport protein that can transport chemotherapeutic drugs (making them resistant to the chemotherapy)
Antigen References: Hoque KM, et al. 2020. Nat Commun. 11:2767. Jonker JW, et al. 2005. Nat Med. 11:127-9. Zhou E, et al. 2005. Blood. 105:2571-6. Kina T, et al. 2000. Br J Haem. 109:280-7.
Gene ID: 26357
UniProt: View information about CD338 on UniProt.org
Clone: S17006D
Regulatory Status: RUO
Other Names: ABCG2, CDw338, Bcrp1, MXR, ABCP, MRX, BMDP
Isotype: Rat IgG2b, κ