Biolegend, 315505, Purified anti-human CD26 Antibody, 100μg

CD26, also known as ADA-binding protein and dipeptidyl peptidase IV (DPPIV), is a 110 kD type II membrane protein. It is a member of the peptidase and ectoenzyme family. CD26 is expressed on the membrane of mature thymocytes, T lymphocytes (upregulated upon activation), B cells, NK cells, and macrophages. CD26 cleaves off N-terminal X-Pro and X-Ala dipeptides from polypeptides. It plays an integral role as a costimulatory molecule in T cell activation. CD26 may interact with extracellular matrix proteins such as fibronectin or collagen, CD45 and ADA.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human DPP4 (AA 41-766)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_3717110 (BioLegend Cat. No. 315505)
Structure: Peptidases and ectoenzyme families, type II glycoprotein, 110 kD
Distribution: Thymocyte subset, memory T cells, B cells, NK cells, epithelial cells, macrophages
Function: Dipeptidyl peptidase, T cell costimulation, HIV entry
Ligand/Receptor: Adenosine-deaminase, collagen
Cell Type: B cells, Epithelial cells, Macrophages, NK cells, T cells, Thymocytes
Biology Area: Costimulatory Molecules, Immunology
Molecular Family: CD Molecules
Antigen References: Kameoka J, et al. 1993. Science. 261:466-9. Dang N, et al. 1990. J. Exp. Med. 172:649-52.
Gene ID: 1803
UniProt: View information about CD26 on UniProt.org
Clone: A21111E
Regulatory Status: RUO
Other Names: Dipeptidyl peptidase-4, adenosine deaminase complexing protein 2, ADA-binding protein, DPP IV ectoenzyme, EC 3.4.14.5, DPP4
Isotype: Mouse IgG2b, κ