Biolegend, 337501, Purified anti-human CD155 (PVR) Antibody, 25μg

CD155, known as poliovirus receptor (PVR) or nectin-like 5, is a 70 kD type I transmembrane glycoprotein. It is a nectin-like molecule belonging to Ig superfamily. CD155 is primarily found on endothelial cells, monocytes, epithelia and central nervous system. CD155 is an adhesion molecule involved in cell-cell and cell-matrix adhesion through interaction with CD226, CD96 (Tactile), nectin-1, -2, and -3 (CD111, CD112, CD113), and vitronectin. It also serves as a receptor for poliovirus and cytomegalovirus.
25μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Additional reported applications include: partially inhibits NK- and T-cell mediated cytotoxicity
Application References(PubMed link indicates BioLegend citation): Tahara-Hanaoka S, et al. 2004. Intl. Immunol. 16:533
RRID: AB_1279096 (BioLegend Cat. No. 337502)
Structure: Type I glycoprotein, Ig superfamily
Distribution: Monocytes, endothelial cells, epithelia, central nervous system
Ligand/Receptor: CD226, CD96, nectin-1, -2, and -3, vitronectin, CD155, poliovirus
Cell Type: Monocytes, Endothelial cells, Epithelial cells, Tregs
Biology Area: Immunology, Innate Immunity
Molecular Family: Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors
Antigen References: 1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication 2. Fuchs A, et al. 2004. J. Immunol. 172:3994 3. Bottino PD, et al. 2005. Mol. Immunol. 42:463
Gene ID: 5817
UniProt: View information about CD155 on UniProt.org
Clone: TX24
Regulatory Status: RUO
Other Names: Poliovirus receptor (PVR), nectin-like 5
Isotype: Mouse IgG2a, λ