Biolegend, 342802, Alexa Fluor® 647 anti-human CD305 (LAIR1) Antibody, 100tests

CD305, also known as LAIR-1 (leukocyte-associated Ig-like receptor-1), is a 40 kD type I transmembrane glycoprotein. LAIR-1 and LAIR-2 are the only members of the LAIR family in the Ig superfamily. LAIR-1 is an inhibitory molecule characterized by ITIMs in the cytoplasmic domain and collagen ligands. CD305 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells. LAIR-1 functions in the inhibition of cell cytotoxicity, cell activation, proliferation and differentiation.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses
Excitation Laser: Red Laser (633 nm)
Application References(PubMed link indicates BioLegend citation): Poggi A, et al. 1995. Eur. J. Immunol. 25:369
Product Citations: van der Wijst MGP, et al. 2021. Sci Transl Med. 13:eabh2624. PubMed Seery V, et al. 2021. EBioMedicine. 67:103357. PubMed
RRID: AB_1659239 (BioLegend Cat. No. 342801) AB_2133480 (BioLegend Cat. No. 342802)
Structure: 40 kD type I transmembrane protein, cytoplasmic domain contains ITIM motifs, Ig superfamily
Distribution: NK cells, T cell, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells
Function: Inhibition of cell cytotoxicity, cell activation, proliferation and differentiation
Ligand/Receptor: collagens
Cell Type: B cells, Basophils, Dendritic cells, Eosinophils, Macrophages, Mast cells, Monocytes, NK cells, T cells
Biology Area: Immunology, Inhibitory Molecules, Innate Immunity
Molecular Family: CD Molecules
Antigen References: 1. Meyaard L, et al. 2008. J. Leukoc. Biol. 83:799 2. Lebbink RJ, et al. 2006. J. Exp. Med. 203:1419
Gene ID: 3903
UniProt: View information about CD305 on UniProt.org
Clone: NKTA255
Regulatory Status: RUO
Workshop: HCDM listed
Other Names: LAIR-1 (Leukocyte-associated Ig-like receptor 1)
Isotype: Mouse IgG1, κ