Biolegend, 377108, PE anti-human OSMR Antibody, 100tests

Oncostatin M receptor (OSMR), also known as IL-31 receptor subunit beta, is a member of the IL-6 receptor family. It is expressed in bone marrow, endothelium, liver, lung and skin tissues. OSMR forms the type II OSM receptor complex when paired with interleukin 6 signal transducer (gp130) and forms the IL-31 receptor when complexed with interleukin 31 receptor A (IL31RA). The binding of OSM to either of these receptors triggers activation of the JAK-STAT signaling pathway.
100tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human OSMR protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes: Clone S22005H does not affect the binding of clone S22005D on target cells.
Structure: Transmembrane immunoglobulin-like glycoprotein, 130 kD
Distribution: Hepatocytes, mesothelial cells, glial cells and epithelial cells
Function: Ligand binding, signal transduction
Interaction: gp130, IL-31RA
Ligand/Receptor: IL-31, OSM
Antigen References: Mosley B, et al. 1996. J Biol Chem. 271:32635. Auguste P, et al. 1997. J Biol Chem. 272:15760. Hermanns HM, et al. 1999. J. Immunol. 163:6651.
Gene ID: 9180
UniProt: View information about OSMR on UniProt.org
Clone: S22005H
Regulatory Status: RUO
Other Names: IL-31 receptor subunit beta, oncostatin-M specific receptor beta subunit
Isotype: Mouse IgG2a, κ
Q: What type of PE do you use in your conjugates?
A: We use R-PE in our conjugates.