Biolegend, 378505, APC anti-human ROR2 Antibody, 25tests

ROR2 is a receptor protein tyrosine kinase that belongs to the ROR subfamily of cell surface receptors. Both canonical and non-canonical Wnt proteins bind to the ROR2 receptor. ROR2 may play a role during embryonic development in the formation of chondrocytes and cartilage and growth plate development and mediates WNT5A-induced noncanonical Wnts signaling, which induces filopodia formation and cell migration.
25tests
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Transfectant AA 1-472
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
RRID: AB_3068221 (BioLegend Cat. No. 378505) AB_3068221 (BioLegend Cat. No. 378506)
Structure: Single-pass type I membrane protein
Distribution: Cell membrane
Function: ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, Wnt protein binding, transmembrane receptor protein tyrosine kinase activity
Interaction: Frizzled binding, mitogen-activated protein kinase kinase kinase binding
Ligand/Receptor: Wnt5a
Biology Area: Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability
Molecular Family: Protein Kinases/Phosphatase
Antigen References: Masiakowski P, et al. 1992. J Biol Chem. 267:26181-90. O'Connell MP, et al. 2010. Oncogene. 29:34-44. Liu Y, et al. 2008. J Cell Biochem. 105:497-502. Schwarzer W, et al. 2009. Hum Mol Genet. 18:4013-21.
Gene ID: 4920
UniProt: View information about ROR2 on UniProt.org
Clone: W19338B
Regulatory Status: RUO
Other Names: Tyrosine-protein kinase transmembrane receptor ROR2 , Neurotrophic tyrosine kinase, receptor-related 2,
Isotype: Rat IgG1, κ