Biolegend, 390002, Purified anti-human CD138 (Syndecan-1) Antibody, 100μg

CD138, also known as Syndecan-1, is a type I integral membrane heparin sulfate proteoglycan.  As a member of the syndecan protein family, Syndecan-1 mediates multiple cellular processes, including migration, proliferation, and cell-matrix adhesion through interactions with collagen, fibronectin, and other soluble molecules (such as FGF-basic). It is expressed on normal and malignant plasma cells, pre-B cells, mesenchymal cells, epithelial cells, and endothelial cells.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant human syndecan-1 protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Clone S22003B does not affect the binding of clones MI15, DL-101, S22003D, and S22003F on target cells. Binding of clone S22003B on fixed target cells is not significantly reduced compared to un-fixed cells.
RRID: AB_3106064 (BioLegend Cat. No. 390002)
Structure: 100-200 kD type I transmembrane glycoprotein
Distribution: Plasma cells, pre-B cells, epithelial cells, endothelial cells
Function: Adhesion, controls cell morphology, regulates cell growth
Ligand/Receptor: FGFb, collagen, fibronectin
Cell Type: B cells, Endothelial cells, Epithelial cells, Plasma cells
Biology Area: Cell Adhesion, Cell Biology, Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Sanderson RD, et al. 1992. Cell Regul. 1:27. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers. Wiley-Liss A John Wiley & Sons Inc, Publication.
Gene ID: 6382
UniProt: View information about CD138 on UniProt.org
Clone: S22003B
Regulatory Status: RUO
Other Names: Syndecan-1, B-B4
Isotype: Rat IgG2a, κ