Biolegend, 394202, Purified anti-human IL12RB2 Antibody, 100μg

IL12RB2 is a type I transmembrane protein that foms an heterodimer with IL12RB1 to produce the high affinity IL-12 receptor complex. IL12RB2 is expressed by activated T cells, TH1 cells, NK cells, B cells and plasma cells. Variants of this gene are associated with predisposition to various immune-related diseases.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human IL12RB2 transfected cells.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Preechanukul A, et al. 2023. iScience. 107234:26. PubMed
RRID: AB_2734483 (BioLegend Cat. No. 394202)
Structure: Type I transmembrane protein, 3 isoforms, foms an heterodimer with IL12RB1
Distribution: Activated T cells, TH1 cells, NK cells, B cells, plasma cells
Function: Role in TH1 differentiation
Ligand/Receptor: IL-12
Cell Type: B cells, NK cells, Plasma cells, T cells, Th1
Biology Area: Immunology
Molecular Family: Cytokine/Chemokine Receptors
Antigen References: LaMere SA, et al. 2017. J Immunol. 199:3158 Prigione I, et al. 2016. Immunobiology. 221:291 de Paus RA, et al. 2013. Mol Immunol. 56:380 Airoldi I, et al. 2008. Blood. 112:750
Gene ID: 3595
UniProt: View information about IL12RB2 on UniProt.org
Clone: S16020B
Regulatory Status: RUO
Other Names: Interleukin-12 receptor subunit beta-2
Isotype: Mouse IgG2a, κ