Biolegend, 395502, Purified anti-human CD288 (TLR8) Antibody, 100μg

Toll-like receptor (TLR) 8, also known as CD288, is a 83 kDa, type 1 transmembrane protein, member of the TLR receptor family. TLR8 is expressed intracellulary in monocytes, macrophages and myeloid dendritic cells, and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR8 triggers anti-viral reponses promoting the secretion of proinflammatory cytokines such as IL-12 and TNF.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human TLR8-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2783317 (BioLegend Cat. No. 395502)
Structure: 83 kD, Type 1 transmembrane protein
Distribution: Endosomal compartments of monocytes, macrophages, myeloid dendritic cells, and neutrophils
Function: Binds single-stranded RNA
Interaction: MYD88, TRAF6, IRAK4
Ligand/Receptor: Single-stranded GU-rich RNA
Cell Type: Dendritic cells, Macrophages, Monocytes, Neutrophils
Biology Area: Immunology, Innate Immunity
Molecular Family: CD Molecules, Toll Like Receptors
Antigen References: Lood C, et al. 2017. J Exp Med. 214:2103. Prinz N, et al. 2011. Blood. 118:2322. Gringhuis SI, et al. 2010. Nat Immunol. 11419. Cros J, et al. 2010. Immunity. 33:375. Peng G, et al. 2005. Science. 309:1380.
Gene ID: 51311
UniProt: View information about CD288 on UniProt.org
Clone: S16018A
Regulatory Status: RUO
Other Names: CD288, Toll-like receptor 8
Isotype: Mouse IgG2a, κ