Biolegend, 439304, ELISA MAX™ Deluxe Set Human APRIL/TNFSF13, 5plates

APRIL, or TNFSF13, stands for “A Proliferation-Inducing Ligand.” It is a member of the TNF superfamily of ligands, closely related to BAFF, with which it shares 30% amino acid sequence identity. APRIL is cleaved intracellularly by furin, and is believed to exist mainly as a secreted, soluble form. APRIL exists as a functional homotrimer (total MW = 90 kD). It can bind to two cell-surface receptors: BCMA and TACI, which it shares with BAFF, to exert downstream T- and B-cell regulatory effects. It also possesses a heparin binding domain and has been demonstrated to bind to proteoglycans on the cell surface. APRIL is known for its tumor proliferation effects. It is a potential biomarker, with serum levels elevated for certain cancers, and expression levels elevated in cancer tissues. It is also a potential biomarker for certain autoimmune diseases.
5plates
Verified Reactivity: Human
Application: ELISA
Sensitivity: 0.06 ng/mL
Standard Range: 0.16 – 10 ng/mL
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Signal Transduction
Molecular Family: Cytokines/Chemokines
Gene ID: 8741
UniProt: View information about APRIL on UniProt.org
Regulatory Status: RUO
Other Names: A Proliferation Inducing Ligand (APRIL), TALL-2, APOL-related leukocyte expressed ligand 2, CD256, member 13, TNF-related death ligand 1, TRDL-1, tumor necrosis factor (ligand) superfamily, ZTNF2
Q: Do the ELISA MAX™ Deluxe Sets come with plates?
A: No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.