Biolegend, 612162, Purified anti-human LRRK2 Antibody, 100μg

Leucine-rich repeat kinase 2 (LRRK2), is a member of the leucine-rich repeat kinase family. This protein also functions as a GTPase. Proteins with leucine-rich regions play a role in protein-protein interactions and mediate assembly of the cell's structural framework (cytoskeleton). Mutations in LRRK2 genes have been associated with late-onset Parkinson's disease.
100μg
Verified Reactivity: Human
Antibody Type: Polyclonal
Host Species: Goat
Immunogen: Recombinant Human Lrrk2 (carrier-free)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: Direct ELISA - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.
Additional Product Notes: This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone Poly23A19) could function as a capture and detection antibody as a self-pairing antibody and using Recombinant Human LRRK2 (carrier-free) protein as the assay standard. For assay development flexibility purposes, this product is provided as a purified format.
RRID: AB_3720589 (BioLegend Cat. No. 612162)
Structure: Dimer
Distribution: Tissue distribution: Lung, Kidney, parathyroid gland, CNS Cellular distribution: cytoplasm, mitochondrion, nucleus, endoplasmic reticulum, lysosome, Golgi apparatus, endosome
Function: LRRK2 interacts with the C-terminal R2 RING finger domain of parkin. LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. Mutations in this gene have been associated with Parkinson disease.
Biology Area: Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
Molecular Family: Mitochondrial Markers
Antigen References: Paisán-Ruíz C, et al. 2004. Neuron. 44(4):595-600. Alegre-Abarrategui J, et al. 2009. Hum. Mol. Genet. 18(21):4022-34. Gómez-Suaga P, et al. 2012. Hum. Mol. Genet. 21(3):511–25. Orenstein SJ, et al. 2013. Nat. Neurosci. 16(4):394–406. Cherra SJ, et al. 2013. Am. J. Pathol. 182(2):474–84.
Gene ID: 120892
UniProt: View information about LRRK-2 on UniProt.org
Clone: Poly23A19
Regulatory Status: RUO
Other Names: Leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid arthritis 17, AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Isotype: Goat Polyclonal IgG