Biolegend, 618401, Purified anti-SENP2 Antibody, 25μg

In eukaryotes, sumoylation (SUMO) is a post-translational modification that contributes to the degradation of proteins harboring the modification. Sentrin-specific protease 2 (SENP2) is an enzyme that is critical for maintaining SUMO homeostasis. There are six described SENP isoforms; each share a highly- conserved catalytic domain in the C-terminus region. SENP2 is localized to the nucleus and catalyzes the deconjugation of SUMO1/2/3 moieties from target proteins. SENP2 has been shown to regulate the level of p53 by desumoylating Mdm2.
25μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Synthetic human SENP2 peptide corresponding to amino acids 562-578
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: We do not recommended this clone for IP or ICC applications.
RRID: AB_2810677 (BioLegend Cat. No. 618401) AB_2810678 (BioLegend Cat. No. 618402)
Structure: SENP2 is a 589 amino acid protein with a predicted molecular weight of 67.9 kD.
Distribution: Nucleus and nuclear pore complex/ubiquitously expressed
Function: Protein turnover
Biology Area: Cell Biology
Molecular Family: Protein Modifiers
Antigen References: Hang J and Dasso M. 2002. J.Biol. Chem. 277:19961 Chiu SY, et al. 2008. PLoS Biol. 6:e310 Nayak A and Müller S. 2014. Genome Biol.15:422
Gene ID: 59343
UniProt: View information about SENP2 on UniProt.org
Clone: W17126B
Regulatory Status: RUO
Other Names: SUMO Specific Peptidase 2, SUMO1/Sentrin/SMT3 Specific Peptidase 2, SUMO1/Sentrin/SMT3 Specific Protease 2, Sentrin/SUMO-Specific Protease SENP2, Sentrin (SUMO1) Specific Peptidase 2, SMT3-Specific Isopeptidase 2, Sentrin-Specific Protease 2
Isotype: Rat IgG2b, κ