Biolegend, 676002, Purified anti-TIMP-1 Antibody, 100μg

TIMP-1 (Tissue inhibitor of metalloproteinase 1) is a glycoprotein that is well recognized for its role in extracellular matrix remodeling through controlling the activity of matrix metalloproteinases (MMPs). Independent of MMP inhibition, TIMPs also act as signaling molecules and plays important roles in cell growth, apoptosis, differentiation, angiogenesis, and oncogenesis. High level of TIMP-1 protein has been found in several types of cancers and associated with a poor patient prognosis. TIMP-1 may be useful as a cancer prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1).
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human TIMP-1.
Formulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: Affinity purified.
Concentration: 0.5 mg/ml
Storage & Handling: Upon receipt, store undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2565609 (BioLegend Cat. No. 676002)
Structure: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD.
Distribution: Widely expressed in mammalian tissues, notably in reproductive organs.
Function: TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes.
Interaction: MMP-1, MMP-3, MMP-9.
Ligand/Receptor: CD63.
Biology Area: Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology
Molecular Family: Enzymes and Regulators
Antigen References: 1. Brew K and Nagase H. 2010. Biochim. Biophys. Acta. 1803:55. 2. Murphy G. 2011. Genome Biol. 12:233. 3. Bourboulia D and Stetler-Stevenson WG. 2010. Semin. Cancer Biol. 20:161. 4. Kim YS, et al. 2012. BMB Rep. 45:623. 5. Ries C. 2014. Cell Mol. Life Sci. 71:659.
Gene ID: 30949
UniProt: View information about TIMP-1 on UniProt.org
Clone: M2004D03
Regulatory Status: RUO
Other Names: Erythroid-potentiating activity (EPA), Fibroblast collagenase inhibitor, Tissue inhibitor of metalloproteinases 1 (TIMP1)
Isotype: Mouse IgG2b, κ