Biolegend, 683202, Purified anti-CCL11 Antibody, 500μg

CCL11 is a member of the CC chemokine family. It was originally identified as a chemoattractant for eosinophils, and participates in a variety of allergic responses to allergens. CCL11 induces angiogenic responses in CCR3 + microvascular endothelial cells and facilitates the proliferation and metastasis of CCR3 + tumor cells.
500μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant Mouse CCL11, (amino acids (His24-Pro97, Accession# NM_011330), were expressed in E. coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: ELISA Capture - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by ELISA. For ELISA capture applications, a concentration of 0.5 µg/mL is recommended. To obtain a linear standard curve, serial dilutions of CCL11 recombinant protein ranging from 500 to 7.81 pg/mL are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance.
RRID: AB_2686953 (BioLegend Cat. No. 683202)
Structure: Chemokine
Distribution: Epithelial cells, smooth muscle cells, dendritic cells, fibroblasts, mast cells, and Th2 lymphocytes.
Function: Recruits eosinophils in allergic responses. Stimulates eosinophil release from bone marrow, increasing levels of circulating eosinophils. Induced by pro-inflammatory cytokines (IL-4, IL-13, TNF-7alpha;, and IFN-α).
Interaction: Eosinophils
Ligand/Receptor: CCR3
Cell Type: Epithelial cells, Dendritic cells, Fibroblasts, Mast cells, Th2, Eosinophils
Biology Area: Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family: Cytokines/Chemokines
Antigen References: 1. Crump MP, et al. 1998. J. Biol. Chem. 273:22471. 2. Conroy DM, et al. 2001. Respir. Res. 2:150. 3. Salcedo R, et al. 2001. J. Immunol. 166:7571. 4. Hadjicharalambous C, et al. 2004. J. Allergy Clin. Immunol. 113:657. 5. Kaehler J, et al. 2006. J. Investig. Med. 54:446. 6. Levina V, et al. 2009. Clin. Cancer Res. 15:2647.
Gene ID: 20292
UniProt: View information about CCL11 on UniProt.org
Clone: L403H11
Regulatory Status: RUO
Other Names: Eotaxin, eotaxin-1, small inducible cytokine subfamily A, member 11 (SCYA11)
Isotype: Rat IgG1, κ