Biolegend, 830201, Purified anti-IL-17F Antibody (Previously Covance catalog# MMS-5118), 100microl

Interleukin 17F (IL-17F) is a 37 kD IL-17 family member.  The IL-17 family consists of six members including IL-17 (also called IL-17A), IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F.  IL-17F shares the strongest similarity to IL-17A and forms a homodimer or heterodimer with IL-17A. It is produced by Th17 cells, mast cells, basophils, and epithelial cells.  IL-17F is an important regulator of inflammatory responses.  It is involved in host defense against mucoepithelial infection by Staphylococcus aureus and Citrobacter rodentium.  Overexpression of the IL-17F gene in the airways of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. IL-17F is also involved in cancer immunity and autoimmune responses. IL-17F, like IL-17A, depends on IL-17R for its signaling in vitro and in vivo .  P38 MAPK, ERK1/2, Act1 (NF-kB activator protein 1), and TRAF6 are involved in IL-17F signaling.
100microl
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: This monoclonal antibody was raised against a peptide sequence conjugated to KLH corresponding to amino acids 107-120 of human IL-17F protein.
Formulation: Phosphate-buffered solution.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 1 mg/ml
Storage & Handling: This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This antibody is effective in immunoblotting (WB).
RRID: AB_2564936 (BioLegend Cat. No. 830201)
Structure: Expected MW: 15 kD
Biology Area: Cell Biology, Neuroinflammation, Neuroscience
Molecular Family: Cytokines/Chemokines
Antigen References: 1. Dong C. 2008. Immunol. Rev. 226:80. 2. Kolls JK, et al. 2004. Immunity 21:467. 3. Aggarwal S, et al. 2002. J. Leukoc. Biol. 71:1. 4. Yang XO, et al. 2008. J. Exp. Med. 205:1063. 5. Ishigame H, et al. 2009. Immunity 30:108. 6. Hu Y, et al. 2010. J. Immunol. 184:4307.
Gene ID: 112744
UniProt: View information about IL-17F on UniProt.org
Clone: 6B9.H8
Regulatory Status: RUO
Other Names: Interleukin-17F, cytokine ML-1, mutant IL-17F
Previously: Covance Catalog# MMS-5118
Isotype: Mouse IgG1, κ