Biolegend, 846902, Purified anti-Thyroglobulin Antibody, 100μg

Thyroglobulin (Tg) is a dimeric glycoprotein that is predominantly produced by follicular cells of the thyroid. This protein is secreted from the endoplasmic reticulum to the follicular lumen. Tg acts as a substrate for the synthesis of thyroxine (T4) and triiodothyronine (T3) as well as storage of inactive forms of thyroid hormone and iodine .
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant human thyroglobulin protein.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2629663 (BioLegend Cat. No. 846902)
Structure: Thyroglobulin is a 2768 amino acid protein with a molecular mass of 305 kD.
Distribution: Tissue distribution: thyroid. Cellular distribution: extracellular, endoplasmic reticulum and plasma membrane.
Function: Thyroglobulin is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Interaction: HSPA5
Biology Area: Cell Biology, Neuroscience
Molecular Family: Hormones
Antigen References: 1. Ma ZF, Skeaff SA. 2014. Thyroid 24(8):1195-209. PubMed 2. Sellitti DF, Suzuki K. 2014. Thyroid 24(4):625. PubMed 3. Bellet D, et al. 1983. J. Clin. Endocrinol. Metab. 56:530. PubMed
Gene ID: 7038
UniProt: View information about Thyroglobulin on UniProt.org
Clone: BSB-49
Regulatory Status: RUO
Other Names: Tg
Isotype: Mouse IgG1, κ