Biolegend, 847102, Purified anti-α-1-Fetoprotein Antibody, 100μg

α-1-Fetoprotein (AFP) is a major plasma protein produced by the yolk sac and the liver during fetal life. AFP is thought to be the fetal counterpart of serum albumin. Since only traces of AFP are found in adult serum, elevated levels suggest either a benign or malignant lesion of the liver, a Yolk-Sac Carcinoma, or one of a few other tumors.
100μg
Verified Reactivity: Human
Reported Reactivity: Dog
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Cyclic peptide corresponding to amino acids 199-161 of human α-1-Fetoprotein.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P - Quality tested IHC-F, WB - Reported in the literature, not verified in house
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.1 - 1.0 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2629665 (BioLegend Cat. No. 847102)
Structure: AFP is a 609 amino acid protein with a molecular mass of 69 kD.
Distribution: Tissue distribution: fetal liver and yolk sac. Cellular distribution: extracellular, secreted, and cytosol.
Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.
Biology Area: Cancer Biomarkers, Cell Biology, Neuroscience
Antigen References: 1. Jacobsen GK, et al. 1981. Am. J. Surg. Pathol. 5:257. PubMed 2. Peyrol S, et al. 1978. Digestion 18:351. PubMed 3. Tsung SH. 1977. Arch. Pathol. Lab. Med. 101:572. PubMed 4. Goodman ZD, et al. 1985. Cancer 55:124. PubMed 5. Roth LM, et al. 1976. Cancer 37:812. PubMed
Gene ID: 174
UniProt: View information about alpha-1-Fetoprotein on UniProt.org
Clone: BSB-23
Regulatory Status: RUO
Other Names: Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP, AFP
Isotype: Mouse IgG2a, κ