Biolegend, 859801, Purified anti-LDHB Antibody, 25μg

Lactate Dehydrogenase B (LDHB) is one of the subunits of the lactate dehydrogenase enzyme that catalyzes the synthesis of (S)-Lactate from pyruvate.  LDHB was shown to be a downstream mediator of the mTOR signaling pathway that plays a critical role in hyperactive mTOR-mediated tumorigenesis, indicating it as potential therapeutic target for cancer and other diseases caused by aberrant mTOR signaling.
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant Lactate Dehydrogenase B (LDHB) expressed in E.coli
Formulation: 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Application: WB - Quality tested IHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application. For formalin-fixed paraffin-embedded immunohistochemical staining, a concentration range of 1 - 5 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810734 (BioLegend Cat. No. 859801)
Structure: LDHB is a 334 amino acid protein with an apparent molecular mass of ~37 kD.
Distribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Cytosol
Function: LDHB is part of the lactate synthesis pathway that synthesizes S-Lactate from pyruvate
Interaction: Forms Homotetramers
Cell Type: Mature Neurons
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cancer Biomarkers
Molecular Family: Enzymes and Regulators
Antigen References: Swiderek K and Paneth P. 2011. Arch. Biochem Biophys. 505(1):33 Zha X, et al. 2011. Cancer Res. 71(1):13
Gene ID: 39451683224534
UniProt: View information about LDHB on UniProt.org
Clone: BL28598
Regulatory Status: RUO
Other Names: LDHB
Isotype: Mouse IgG2b, κ