Biolegend, 863801, Purified anti-LBP Antibody, 25μg

LPS-binding protein (LBP) is a protein that binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), which is a glycolipid present in the outer membrane of all Gram-negative bacteria. It is involved in the immunological response to infections of Gram-negative bacteria, together with bactericidal permeability-increasing protein (BPI). LBP also interacts with the CD14 receptor and enhances its association with LPS. LBP is associated with diseases including bacterial sepsis, and is related to cytokine release in response to bacteria in immune system.
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Polyclonal
Host Species: Rabbit
Immunogen: Recombinant LBP expressed in E.coli.
Formulation: 0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: Store at 4°C for up to 3 months. For longer term storage, aliquot into small volumes and store at -20°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Heymann CJF, et al. 2022. J Bone Oncol. 36:100451. PubMed Heymann CJF, et al. 2021. Cancer Lett. 522:63. PubMed
RRID: AB_2820150 (BioLegend Cat. No. 863801)
Structure: LBP is a 481 amino acid protein with an apparent molecular mass of ~53 kD.
Distribution: Tissue Distribution: Brain, kidney, lung, and immune system Cellular Distribution: Extracellular, nucleus, and membrane
Function: Innate immune response
Interaction: LPS, BPI, CD14 receptor
Cell Type: Mesenchymal cells, Monocytes, Neurons
Biology Area: Bacterial proteins and Toxins, Cell Biology, Immunology, Neurodegeneration, Neuroscience
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Pretorius E, et al. 2018. PLoS One. 13(3): e0192121. Sakura T, et al. 2017. Cardiovasc Diabetol. 16(1):62. Worthmann H, et al. 2015. J Neuroinflammation. 12:13.
Gene ID: 39291680329469
UniProt: View information about LBP on UniProt.org
Clone: Poly28638
Regulatory Status: RUO
Other Names: LPS-Binding Protein, Lipopolysaccharide Binding Protein, Lipopolysaccharide-Binding Protein, BPI Fold Containing Family D, Member 2, BPIFD2
Isotype: Rabbit Polyclonal IgG