Biolegend, 865502, Purified anti-Gemin 3 Antibody, 100μg

Gemin 3, also known as DEAD-box helicase 20 (DDX20), is a putative RNA helicase that contains a conserved ASP-GLU-ALA-ASP (DEAD) motif. Gemin 3 is involved in a variety of cellular processes including initiation of protein translation, ribosome assembly, and alteration of RNA secondary structure. Gemin 3 is one of the core components of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. Gemin 3 may also be involved in cancer as it acts as a tumor suppressor in hepatocellular carcinoma, and as a tumor promoter in breast cancer and prostate cancer 2 .
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810775 (BioLegend Cat. No. 865501) AB_2810776 (BioLegend Cat. No. 865502)
Structure: Gemin 3 is an 824 amino acid protein with an apparent molecular mass of ~ 92 kD.
Distribution: Tissue Distribution: Testis and ovary Cellular Distribution: Cytosol, nucleus, and cytoskeleton
Function: Gemin 3 is a component of SMN macromolecule protein complex.
Interaction: SMN, GEMIN4
Cell Type: Astrocytes, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes
Biology Area: Cancer Biomarkers, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors
Antigen References: Seng CO, et al. 2015. Hum. Mol. Genet. 24(8):2138. Chen W, et al. 2016. Int. J. Mol. Med. 37(6):1551.
Gene ID: 11218
UniProt: View information about Gemin 3 on UniProt.org
Clone: 12H12
Regulatory Status: RUO
Other Names: Gemin3
Isotype: Mouse IgG1, κ