Biolegend, 865802, Purified anti-Phostensin Antibody, 100μg

Phostensin is a protein that targets protein phosphatase 1 (PP1) to F-actin cytoskeleton. The phostensin/PP1 complex is involved in actin cytoskeleton remodeling. Diseases associated with phostensin include deafness and  autosomal recessive 79.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant human phostensin protein fragments expressed in E.coli
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 5.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 2.0 - 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810781 (BioLegend Cat. No. 865801) AB_2810782 (BioLegend Cat. No. 865802)
Structure: Phostensin is a 613 amino acid protein with an observed molecular mass of ~100 kD.
Distribution: Tissue Distribution: Brain, spleen, lymph node, and leukocytes Cellular Distribution: Cytoskeleton, nucleus, and cytosol
Function: Phostensin is involved in the regulation of protein phosphase-1 activity by targeting it to the F-actin cytoskeleton.
Interaction: Protein Phosphatase-1, F-actin
Cell Type: Lymphocytes, Neurons
Biology Area: Cell Biology, Immunology, Neurodegeneration, Neuroscience, Signal Transduction
Molecular Family: Cytoskeletal Proteins, Enzymes and Regulators, Phospho-Proteins, Protein Modifiers
Antigen References: Matsubara T, et al. 2018. Mol Cell Biol. 38(4). pii: e00425. Lin YS, et al. 2011. J Histochem Cytochem. 59(8):741.
Gene ID: 170954
UniProt: View information about Phostensin on UniProt.org
Clone: 4B12-E11-D9
Regulatory Status: RUO
Other Names: Protein Phosphatase 1 Regulatory Subunit 18, Protein Phosphatase 1 F-Actin Cytoskeleton Targeting Subunit, KIAA1949
Isotype: Mouse IgG1, κ