Biolegend, 866401, Purified anti-Ezrin Antibody, 25μg

Ezrin, a member of the ERM (Ezrin-Radixin-Moesin) family, is a linker protein between cytoskeleton and cellular membrane. It has wide temporal and spatial expression, and participates in a variety of cellular processes such as cell adhesion, cell motility, cell-cell communication, and apoptosis. High levels of Ezrin expression promotes tumorigenesis in tissues, including glioblastoma, breast cancer, and colon cancer. Ezrin is also highly expressed in neural stem cells and neuroblasts, where it may function in actin remodeling.
25μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant full length human Ezrin protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. For immunohistochemistry, a concentration range of 1.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Soto JS, et al. 2023. Nature. 616:764. PubMed
RRID: AB_2810785 (BioLegend Cat. No. 866401) AB_2810786 (BioLegend Cat. No. 866402)
Structure: Human Ezrin is a 586 amino acid protein with a molecular mass of 70 kD.
Distribution: Tissue distribution: Cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve Cellular distribution: Cytoskeleton and plasma membrane
Function: Ezrin is involved in the connection of major cytoskeletal structures to the plasma membrane.
Interaction: Interacts with many proteins, such as MPP5, SLC9A3R2, MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B
Cell Type: Astrocytes, Leukocytes, Neural Stem Cells, Neurons, Oligodendrocytes, T cells
Biology Area: Cell Adhesion, Cell Motility/Cytoskeleton/Structure, Cell Structure, Neurodegeneration, Neuroinflammation, Neuroscience
Molecular Family: Cytoskeletal Proteins, Scaffold Proteins
Antigen References: Moon Y, et al. 2013. Histochem. Cell. Biol. 139:403-13. Xie JJ, et al. 2011. J. Histochem. Cytochem. 59(11):1001-8.
Gene ID: 7430
UniProt: View information about Ezrin on UniProt.org
Clone: CPTC-Ezrin-1
Regulatory Status: RUO
Other Names: Cytovillin, Cytovillin 2, CVIL, CVL, Villin-2, VIL2, p81, HEL-S-105
Isotype: Mouse IgG2b, κ