Biolegend, 867602, Purified anti-Dynactin 1 (N-Terminus) Antibody, 100μg

Dynactin 1 is the largest subunit of the macromolecular complex dynactin, which is essential for dynein-mediated retrograde transport of vesicles and organelles. Dynactin 1 is clinically identified as a causative gene for Perry syndrome (PS), which is a neurodegenerative disease characterized by autosomal dominant inheritance, parkinsonism, and central hypoventilation. Mutations in dynactin 1 are also associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant Dynactin 1 protein fragments expressed in E.coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2814614 (BioLegend Cat. No. 867601) AB_2814615 (BioLegend Cat. No. 867602)
Structure: Dynactin 1 is a 1278 amino acid protein with two reported isoforms. A brain-specific isoform with predicted and observed molecular mass of ~135 kD, and a ubiquitously expressed isoform with predicted and observed molecular mass of ~150 kD.
Distribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Cytoskeleton, cytosol, and nucleus
Function: Dynactin 1 recruits dynein to microtubules and facilitates retrograde transport of vesicles and organelles.
Interaction: Dynactin 1 forms homodimer and interacts with dynein.
Biology Area: Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance, Synaptic Biology
Molecular Family: Adaptor Proteins, Carrier Proteins, Cytoskeletal Proteins, Neurotransmitter Receptor Trafficking/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
Antigen References: Konno T, et al. 2017. Parkinsonism Relat Disord. 41:14. Houlden H, et al. 2012. Acta Neuropath. 124(3):325. Tanaka F, et al. 2011. Rinsho Shinkeigaku. 51(11):1189.
Gene ID: 1639
UniProt: View information about Dynactin 1 on UniProt.org
Clone: 3D5-C6-D5
Regulatory Status: RUO
Other Names: DCTN1, Dynactin Subunit 1
Isotype: Mouse IgG1, κ