Biolegend, 868702, Purified anti-CKMT2 Antibody, 100μg

CKMT2 is an isoform of the mitochondrial specific creatine kinase subunit that is mainly expressed in skeletal and heart muscle cells. CKMT2 exists in two different oligomeric forms: dimers and octamers. Recent studies have shown that the homooctameric form of CKMT2 is the predominant form in vivo and is critical to its function.
100μg
Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P, ICC - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 10 µg/mL is suggested. For immunocytochemistry, a concentration of 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2814623 (BioLegend Cat. No. 868701) AB_2814624 (BioLegend Cat. No. 868702)
Structure: CKMT2 is a 419 amino acid protein with predicted and observed molecular mass of ~47 kD.
Distribution: Tissue Distribution: Mainly expressed in heart and skeletal muscle. Also expressed in brain. Cellular Distribution: Mitochondrion and cytosol
Function: CKMT2 plays a central role in energy transduction in tissues with large, fluctuating energy demands such as the brain.
Interaction: CKMT2 exists as octamer composed of four homodimers.
Biology Area: Mitochondrial Function, Neurodegeneration, Neuroscience
Molecular Family: Mitochondrial Markers
Antigen References: Zervou S, et al. 2017. PLoS One. 12(8):e0182994 Forsey KE, et al. 2013. Mol Reprod Dev. 80(3):185 Miceli MV, et al. 2005. Exp Cell Res. 302 (2):270
Gene ID: 116076722688698
UniProt: View information about CKMT2 on UniProt.org
Clone: 3F4-G5-H5
Regulatory Status: RUO
Other Names: Creatine Kinase, Mitochondrial 2
Isotype: Mouse IgG2b, κ