Biolegend, 870301, Purified anti-Aldose Reductase (AKR1B1) Antibody, 25μg

Aldo-keto reductase 1 member B1 (AKR1B1) is a member of AKR superfamily and catalyzes the NADPH-dependent reduction of a wide range of carbonyl-containing compounds to their corresponding metabolites. It also plays an important role in glucose metabolism. Elevated expression levels of AKR1B1 correlate with breast cancer, neuroinflammation, and astrocyte proliferation via modulating energy metabolism.
25μg
Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant human AKR1B1 protein.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality testedIHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.2 - 5.0 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2820190 (BioLegend Cat. No. 870301) AB_2820191 (BioLegend Cat. No. 870302)
Structure: Human aldose reductase is a 316 amino acid protein with a predicted molecular mass of 36 kD.
Distribution: Tissue distribution: Expressed in a wide range of tissues Cellular distribution: Nucleus, cytosol, extracellular, mitochondrion, lysosome
Function: AKR1B1 plays an important role in cellular metabolism.
Cell Type: Astrocytes, Neurons
Biology Area: Neuroinflammation, Neuroscience
Molecular Family: Enzymes and Regulators
Antigen References: Chen X, et al. 2018. Neurochem Res. 43(8):1491-1499. Steinhauser CB, et al. 2016. Biol Reprod. 95(5):108. Wu X, et al. 2017. J Exp Med. 214(4):1065-1079. Han J, et al. 2016. Proc Natl Acad Sci U S A. 113(50):14283-14288.
Gene ID: 231
UniProt: View information about Aldose Reductase on UniProt.org
Clone: 4G9-B6-F6
Regulatory Status: RUO
Other Names: Aldo-keto reductase family 1 member B1, Aldehyde reductase, Aldose reductase, AR
Isotype: Mouse IgG1, κ